Piperidine → HCID 20356980, compound

HRID 2083673Notes

Reaction equation

HRID 2083673 reaction equation
[C:1]1([C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([CH2:10][CH2:11][CH2:12][Cl:13])[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C(C2C=CC=CC=2)(CCBr)C#N)C=CC=CC=1.[N:38]12[CH2:47][CH2:46][CH2:45][CH2:44][CH:43]1[CH2:42][NH:41][CH2:40][CH2:39]2.N1CCCCC1>>[ClH:13].[ClH:13].[C:1]1([C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([CH2:10][CH2:11][CH2:12][N:41]2[CH2:42][CH:43]3[N:38]([CH2:47][CH2:46][CH2:45][CH2:44]3)[CH2:39][CH2:40]2)[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 8082PiperidineHCID 965754-Bromo-2,2-diphenylbutyronitrileHCID 3240195-chloro-2,2-diphenylpentanenitrileHCID 2876391(+-)-1,4-Diazabicyclo[4.4.0]decane

Product 1

HCID 20356980HCID 20356980, compound

Procedure

Substitution of an equivalent quantity of 2,2-diphenyl-5-chlorovaleronitrile for the 2,2-diphenyl-4-bromobutyronitrile, and 1,4-diazabicyclo[4.4.0]decane for the piperidine used in Example 22, and substantial repetition of the procedure detailed therein, affords 2,2-diphenyl-5-(1,4-diazabicyclo[4.4.0]dec-4-yl)valeronitrile dihydrochloride, melting at about 233° - 238° C. with decomposition.

Sources & evidence

ORD record
ord-f5451d53b0244d27bb5d4f2098e4ea01
Source dataset
uspto-grants-1978_04
Patent number
US04086234

Reaction notes

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