Sodium hydride → HCID 69782740, compound

HRID 2083941Notes

Reaction equation

HRID 2083941 reaction equation
[H-].[Na+].[CH3:3][O:4][C:5](=[O:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)=[CH:9][CH:8]=1>C(=O)(OC)OC>[CH3:3][O:4][C:5](=[O:21])[CH:6]([C:7]1[CH:8]=[CH:9][C:10]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)=[CH:11][CH:12]=1)[C:5]([O:4][CH3:3])=[O:21]

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 12531835HCID 12531835, compound

Product 1

HCID 69782740HCID 69782740, compound

Reagents, catalysts & solvents 1

HCID 12021Dimethyl CarbonateSolvent

Conditions

Temperature
90 °C

Procedure

A suspension of sodium hydride (350 mg) in dimethyl carbonate (10 ml) is treated at room temperature with the product obtained in step D. The mixture is heated to 90° C. for 1 hour, cooled and poured into ice water and extracted with methylene chloride. The extract is dried and evaporated to yield 5.7 of the title compound as an oil.

Workup

  1. temperaturecooled
  2. extractionextracted with methylene chloride
  3. customThe extract is dried
  4. customevaporated

Sources & evidence

ORD record
ord-02c63340c41a44f0976d26e93c163e14
Source dataset
uspto-grants-2004_04
Patent number
US06716845B2

Reaction notes

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