Ethanesulfonyl chloride → HCID 69889873, compound

HRID 2083950Notes

Reaction equation

C(OC([NH:11][CH2:12][CH2:13][CH2:14][C@@H:15]([C:24]([OH:26])=O)[NH:16]C(OC(C)(C)C)=O)=O)C1C=CC=CC=1.[CH2:27]([S:29]([Cl:32])(=[O:31])=[O:30])[CH3:28].[NH:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1>>[ClH:32].[NH2:16][C@H:15]([C:24](=[O:26])[N:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1)[CH2:14][CH2:13][CH2:12][NH:11][S:29]([CH2:27][CH3:28])(=[O:31])=[O:30]

Participants

Reactant 3

HCID 11667Ethanesulfonyl chloride

HCID 31268Pyrrolidine

HCID 7269338(2S)-5-{[(benzyloxy)carbonyl]amino}-2-{[(tert-butoxy)carbonyl]amino}pentanoic acid

Product 1

HCID 69889873HCID 69889873, compound

Procedure

Starting from (S)-N5-(benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-ornithine, ethanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 3.

Sources & evidence

ORD record: ord-011af599e3a44ea5a67ae4e15b889676
Source dataset: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06716843B2

Reaction notes

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