HCID 22732612, compound → HCID 22732610, compound

HRID 2083999Notes

Reaction equation

HRID 2083999 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([N:19]3[CH:24]([C:25]([OH:27])=[O:26])[CH2:23][C:22]4[N:28]([CH3:31])[CH:29]=[N:30][C:21]=4[CH2:20]3)(=[O:18])=[O:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([O-])=O>CN(C)C=O.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[CH:12][C:13]([S:16]([N:19]3[CH:24]([C:25]([OH:27])=[O:26])[CH2:23][C:22]4[N:28]([CH3:31])[CH:29]=[N:30][C:21]=4[CH2:20]3)(=[O:18])=[O:17])=[CH:14][CH:15]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 22732612HCID 22732612, compound

Product 1

HCID 22732610HCID 22732610, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

1 g (2.3 mmol) of 5-(4′-nitrobiphenyl-4-sulfonyl)-1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid was dissolved in 15 ml of dimethylformamide (DMF) and, after addition of 0.1 g of hydrogenation catalyst (10% Pd on activated carbon), quantitatively hydrogenated within 2 h. After removal of the solvent, the crude product was purified by chromatography.

Workup

  1. customAfter removal of the solvent
  2. customthe crude product was purified by chromatography

Sources & evidence

ORD record
ord-e1852b5133f74e88b536aa1af414a1ad
Source dataset
uspto-grants-2004_04
Patent number
US06716853B2

Reaction notes

Loading…