HCID 22732010, compound → HCID 22732055, compound

HRID 2084046Notes

Reaction equation

HRID 2084046 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]=O)=[C:4]([NH:11][CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:3]=1>Cl.CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([CH:8]=[CH:9][N:11]2[CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 22732010HCID 22732010, compound

Product 1

HCID 22732055HCID 22732055, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

4-Bromo-2-[(tetrahydropyran4-yl)amino]-phenylacetaldehyde, dimethyl acetal (522 mg, 1.516 mmol) was dissolved in 20 ml of 1M HCl in methanol. The solution was refluxed for 2 hrs and the solvent evaporated to give the title compound (407 mg, 96%) as an off-white solid.

Workup

  1. temperatureThe solution was refluxed for 2 hrs
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-c5eac003892d4a54995cba4ea9e17bbe
Source dataset
uspto-grants-2004_04
Patent number
US06716837B1

Reaction notes

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