O-Methylhydroxylamine hydrochloride → HCID 85340123, compound

HRID 2084068Notes

Reaction equation

HRID 2084068 reaction equation
O=[C:2]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][C:5]1=[O:9].Cl.[CH3:17][O:18][NH2:19]>>[CH3:17][O:18][N:19]=[C:2]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][C:5]1=[O:9]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 22733081HCID 22733081, compound

Product 1

HCID 85340123HCID 85340123, compoundYield 70%

Procedure

0.3 g (1.47 mmol) of 1-(2-oxo-2-pyridin-3-yl-ethyl)-pyrrolidin-2-one prepared from Example 20 and 0.18 g (2.21 mmol) of methoxyamine hydrochloride salt were treated as described in Example 22 to obtain 0.24 g (70% yield) of 1-(2-methoxyimino-2-pyridin-3-yl-ethyl)-pyrrolidin-2-one as E/Z mixture (2.38:1).

Sources & evidence

ORD record
ord-5fd7cffd7cc54eaab6716a8e29cf0af1
Source dataset
uspto-grants-2004_04
Patent number
US06716857B2

Reaction notes

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