Methanesulfonyl chloride → 3-(3-Benzyloxyphenyl)propyl methanesulfonate

HRID 2084374Notes

Reaction equation

HRID 2084374 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][OH:18])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(N(CC)CC)C>[CH3:19][S:20]([O:18][CH2:17][CH2:16][CH2:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1)(=[O:22])=[O:21]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 126481553-(Phenylmethoxy)benzenepropanol

Product 1

HCID 227333633-(3-Benzyloxyphenyl)propyl methanesulfonate

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Using 3-(3-benzyloxyphenyl)propanol (13.5 g), triethylamine (8.16 ml) and methanesulfonyl chloride(4.53 ml), the same reaction as Reference Example 9-(iv) was carried out to yield the titled compound (19.7 g) as an oily substance.

Workup

  1. customthe same reaction as Reference Example 9-(iv)

Sources & evidence

ORD record
ord-ea30888403ac49ffa83dfa8aa20e4d0f
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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