Sodium Iodide → Benzyl 3-(3-iodopropyl)phenyl ether

HRID 2084375Notes

Reaction equation

HRID 2084375 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:10]=1)(=O)=O.[I-:23].[Na+]>>[I:23][CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[C:11]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 5238Sodium IodideHCID 227333633-(3-Benzyloxyphenyl)propyl methanesulfonate

Product 1

HCID 22733348Benzyl 3-(3-iodopropyl)phenyl etherYield 85%

Procedure

Using 3-[3-(benzyloxy)phenyl]propyl methanesulfonate (19.7 g) and sodium iodide (29.25 g), the same reaction as Reference Example 9-(v) was carried out to yield the titled compound (18.4 g) as an oily substance.

Workup

  1. customthe same reaction as Reference Example 9-(v)

Sources & evidence

ORD record
ord-4ff323bc330e495cb51fb2088897581a
Source dataset
uspto-grants-2004_04
Patent number
US06716863B2

Reaction notes

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