Hydrochloric Acid → HCID 136388368, compound

HRID 2084539Notes

Reaction equation

HRID 2084539 reaction equation
C(OC(=O)[NH:7][C@@H:8]([C:18]([CH3:21])([CH3:20])[CH3:19])[C:9](=[O:17])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[NH2:7][C@@H:8]([C:18]([CH3:21])([CH3:20])[CH3:19])/[C:9](/[OH:17])=[CH:10]/[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 60077773HCID 60077773, compound

Product 1

HCID 136388368HCID 136388368, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(1(S)-tert-Butyl-2-oxo-3-pyridin-2-yl-propyl)-carbamic acid tert-butyl ester (300 mg, 1.0 mmol), was dissolved in dioxane saturated with HCl (20 mL) and the reaction mixture stirred at room temperature for 2 hours. The mixture was then concentrated in vacuo to give the title compound as a yellow solid (0.37 g) which was used in Step C without further purification.

Workup

  1. concentrationThe mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-9800897a7b3f4d61b03359d8b0e491c9
Source dataset
uspto-grants-2004_04
Patent number
US06716878B1

Reaction notes

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