Methyl iodide → 1-Methyl-2-(methylsulfanyl)benzene
Reaction equation
CI.C(=O)([O-])[O-].[K+].[K+].[CH3:9][C:10]1[C:15]([SH:16])=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH3:17]CCCCC>CN(C=O)C.O>[CH3:9][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=1[S:16][CH3:17]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 50 °C
Procedure
Methyl iodide (0.5 mL, 8.1 mmol) and potassium carbonate (1.1 g, 8.1 mmol) were added to a solution of o-thiocresol (1.0 g, 8.1 mmol) in 10 mL of DMF. The reaction was stirred at 50° C. for 4 hours and poured into hexane and water. The organic layer was separated, dried over magnesium sulfate and concentrated to afford 1.1 g of desired material.
Workup
- customThe organic layer was separated
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-c1dfdfc2af7d42d88568500547e094ea
- Source dataset
- uspto-grants-2004_04
- Patent number
- US06716991B1
Reaction notes
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