反应详情

A mixture of trans-4-aminocinnamic acid (0.205 g, 1.26 mmol), 3-chloro-4-(4-chlorophenyl)-1H-pyrrole-2,5-dione (0.123 g, 0.51 mmol) and 1-methyl-2-pyrrolidinone (1.0 mL) was heated in a sealed tube in a hotblock set at 69° C., for 28.5 hours. The mixture was diluted with aqueous hydrochloric acid (10 mL) and extracted with ethyl acetate (2×20 mL). The combined organics were washed with brine (2×10 mL), dried over anhydrous magnesium sulphate and evaporated to dryness. The residue was triturated with a mixture of dichloromethane and ethyl acetate to afford the title compound as a solid.

1. temperaturewas heated in a sealed tube in a hotblock
2. extractionextracted with ethyl acetate (2×20 mL)
3. washThe combined organics were washed with brine (2×10 mL)
4. dry with materialdried over anhydrous magnesium sulphate
5. customevaporated to dryness
6. customThe residue was triturated with a mixture of dichloromethane and ethyl acetate