Ethyl Acetate → HCID 69838355, compound

HRID 2085113Notes

Reaction equation

HRID 2085113 reaction equation
[CH2:1]1[C:5]2=[C:6]3[C:11](=[CH:12][CH:13]=[C:4]2[NH:3][C:2]1=[O:14])[N:10]=[CH:9][CH:8]=[CH:7]3.C(O[CH:20](OC(C)(C)C)[N:21]([CH3:23])[CH3:22])(C)(C)C.C(OCC)(=O)C>CN(C=O)C>[CH3:20][N:21]([CH:23]=[C:1]1[C:5]2=[C:6]3[C:11](=[CH:12][CH:13]=[C:4]2[NH:3][C:2]1=[O:14])[N:10]=[CH:9][CH:8]=[CH:7]3)[CH3:22]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 5477121,1-bis(1,1-dimethylethoxy)-N,N,N-trimethylamineHCID 219070851,3-Dihydro-pyrrolo[3,2-f]quinoline-2-one

Product 1

HCID 69838355HCID 69838355, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 3-H-pyrrolo[3,2-f]quinoline-2-one (13 mmol) and dimethylformamide di-t-butyl acetal (15 mmol) in DMF was stirred at room temperature for 3 h. Ethyl acetate (25 mL) was added and the resulting solid was collected by filtration and allowed to air dry. The desired compound was obtained (70%) and used directly in the next step.

Workup

  1. filtrationthe resulting solid was collected by filtration
  2. customto air dry

Sources & evidence

ORD record
ord-17198fed2ff84398a5f1a4be9f8888ea
Source dataset
uspto-grants-2004_04
Patent number
US06720332B2

Reaction notes

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