Hydrochloric Acid → 6-(3,4-Difluorophenyl)-4-methyl-5-methoxycarbonyl-1-(4-nitrophenoxy)carbonyl-2-oxo-1,2,3,6-tetrahydro-pyrimidine

HRID 2085384Notes

Reaction equation

HRID 2085384 reaction equation
Cl.[F:2][C:3]1[CH:4]=[C:5]([CH:10]2[N:15]([C:16]([O:18][C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=3)=[O:17])[C:14]([O:28]C)=[N:13][C:12]([CH3:30])=[C:11]2[C:31]([O:33][CH3:34])=[O:32])[CH:6]=[CH:7][C:8]=1[F:9]>C1COCC1>[F:2][C:3]1[CH:4]=[C:5]([CH:10]2[N:15]([C:16]([O:18][C:19]3[CH:20]=[CH:21][C:22]([N+:25]([O-:27])=[O:26])=[CH:23][CH:24]=3)=[O:17])[C:14](=[O:28])[NH:13][C:12]([CH3:30])=[C:11]2[C:31]([O:33][CH3:34])=[O:32])[CH:6]=[CH:7][C:8]=1[F:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10671680HCID 10671680, compound

Product 1

HCID 158957606-(3,4-Difluorophenyl)-4-methyl-5-methoxycarbonyl-1-(4-nitrophenoxy)carbonyl-2-oxo-1,2,3,6-tetrahydro-pyrimidineYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Aqueous 6 N hydrochloric acid (10 mL) was added to a stirring solution of 6-(3,4-difluorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-(4-nitrophenoxy)carbonylpyrimidine (10.0 g) in THF (200 mL) at room temperature. The stirring was continued for 3 h. The solvent was evaporated and the residue was dried under vacuum, giving the desired product as a white powder (9.70 g, 100%): mp 185-186° C.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-f2aec87d5c4441e3b4c64c1b5446a944
Source dataset
uspto-grants-2004_04
Patent number
US06720324B2

Reaction notes

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