Hydrochloric Acid → HCID 22725218, compound

HRID 2085415Notes

Reaction equation

HRID 2085415 reaction equation
Cl.[C:2]([C:5]1[CH:10]([C:11]2[CH:16]=[C:15]([F:17])[C:14]([F:18])=[C:13]([F:19])[CH:12]=2)[N:9]([C:20]([O:22][C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=2)=[O:21])[C:8]([O:32]C)=[N:7][C:6]=1[CH3:34])(=[O:4])[CH3:3]>C1COCC1>[C:2]([C:5]1[CH:10]([C:11]2[CH:16]=[C:15]([F:17])[C:14]([F:18])=[C:13]([F:19])[CH:12]=2)[N:9]([C:20]([O:22][C:23]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][CH:24]=2)=[O:21])[C:8](=[O:32])[NH:7][C:6]=1[CH3:34])(=[O:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22725169HCID 22725169, compound

Product 1

HCID 22725218HCID 22725218, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 6 N aqueous HCl (4 mL) was added to a well-stirred solution of 4-nitrophenyl 5-acetyl-2-methoxy-4-methyl-6-(3,4,5-trifluorophenyl)-1(6H)-pyrimidinecarboxylate (4.00 g, 8.63 mmol) in THF (100 mL) at 0-5° C., and the mixture was allowed to warm to room temperature. After 2 h, solvent was evaporated and the product dried under vacuum. The product was obtained as a pure single component and used in the next step without further purification (3.88 g, 100%).

Workup

  1. customsolvent was evaporated
  2. customthe product dried under vacuum
  3. customThe product was obtained as a pure single component
  4. customused in the next step without further purification (3.88 g, 100%)

Sources & evidence

ORD record
ord-835d5490f4f84a2dbe6e4efe70ce1af5
Source dataset
uspto-grants-2004_04
Patent number
US06720324B2

Reaction notes

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