Hydrochloric Acid → HCID 22725218, compound

HRID 2085431Notes

Reaction equation

HRID 2085431 reaction equation
Cl.[F:2][C:3]1[CH:4]=[C:5]([CH:11]2[N:16]([C:17]([O:19][C:20]3[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][CH:21]=3)=[O:18])[C:15]([O:29]C)=[N:14][C:13]([CH3:31])=[C:12]2[C:32](=[O:34])[CH3:33])[CH:6]=[C:7]([F:10])[C:8]=1[F:9]>C1COCC1>[F:2][C:3]1[CH:4]=[C:5]([CH:11]2[N:16]([C:17]([O:19][C:20]3[CH:21]=[CH:22][C:23]([N+:26]([O-:28])=[O:27])=[CH:24][CH:25]=3)=[O:18])[C:15](=[O:29])[NH:14][C:13]([CH3:31])=[C:12]2[C:32](=[O:34])[CH3:33])[CH:6]=[C:7]([F:10])[C:8]=1[F:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22725169HCID 22725169, compound

Product 1

HCID 22725218HCID 22725218, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Aqueous 6 N aqueous HCl (4 mL) was added to a stirring solution of 6-(3,4,5-trifluorophenyl)-1,6-dihydro-2-methoxy-5-acetyl-4-methyl-1-[(4-nitrophenyloxy) carbonyl]pyrimidine (4.0 g, 8.63 mmol) in THF (100 mL) at 0-5° C., and the mixture was allowed to warm to room temperature. After 2 h, the solvent was evaporated and the product was dried under vacuum, giving the desired product as a pure single component which was used in the next step without further purification (3.88 g, 100%).

Workup

  1. customthe solvent was evaporated
  2. customthe product was dried under vacuum

Sources & evidence

ORD record
ord-572e2078c4824671bb62eea3c545efcf
Source dataset
uspto-grants-2004_04
Patent number
US06720324B2

Reaction notes

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