Trifluoroacetic acid → HCID 69827417, compound

HRID 2085638Notes

Reaction equation

HRID 2085638 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][CH2:10][NH:11][CH:12]([CH3:20])[C:13]([O:15]C(C)(C)C)=[O:14])=[CH:4][C:3]=1[C:21](=[O:34])[NH:22][CH2:23][C:24]12[CH2:33][CH:28]3[CH2:29][CH:30]([CH2:32][CH:26]([CH2:27]3)[CH2:25]1)[CH2:31]2.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][CH2:10][NH:11][CH:12]([CH3:20])[C:13]([OH:15])=[O:14])=[CH:4][C:3]=1[C:21](=[O:34])[NH:22][CH2:23][C:24]12[CH2:33][CH:28]3[CH2:29][CH:30]([CH2:32][CH:26]([CH2:27]3)[CH2:25]1)[CH2:31]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86586604HCID 86586604, compound

Product 1

HCID 69827417HCID 69827417, compoundYield 5.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of [2-[4-chloro-3-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)carbamoyl-phenylamino]-ethylamino]-propionic acid, 1,1-dimethylethyl ester (0.20 g, Example 7a) in dichloromethane (5 ml), was added trifluoroacetic acid (2 ml). After 15 h the solution was concentrated and purified by RPHPLC (eluting with 15-95% MeCN in 0.1% AcONH4 aqueous) to afford the title compound as a solid (0.010 g).

Workup

  1. concentrationAfter 15 h the solution was concentrated
  2. custompurified by RPHPLC (eluting with 15-95% MeCN in 0.1% AcONH4 aqueous)

Sources & evidence

ORD record
ord-0ca8ddae22064a57bc9089bf53bbcbad
Source dataset
uspto-grants-2004_04
Patent number
US06720452B2

Reaction notes

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