1-Methylhistamine → HCID 10116086, compound

HRID 2085653Notes

Reaction equation

HRID 2085653 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([NH:22][CH2:23][CH2:24]Cl)=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:5].[CH3:26][N:27]1[CH:34]=[N:33][C:29]([CH2:30][CH2:31][NH2:32])=[CH:28]1.C(N(CC)C(C)C)(C)C.[I-].[K+]>C(O)CCC>[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([NH:22][CH2:23][CH2:24][NH:32][CH2:31][CH2:30][C:29]2[N:33]=[CH:34][N:27]([CH3:26])[CH:28]=2)=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][C:8]12[CH2:15][CH:14]3[CH2:16][CH:10]([CH2:11][CH:12]([CH2:13]3)[CH2:17]1)[CH2:9]2)=[O:5]

Participants

6

Reactant 4

HCID 36141-MethylhistamineHCID 4875Potassium IodideHCID 81531DiisopropylethylamineHCID 114176532-Chloro-5-(2-chloroethyl)amino-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)benzamide

Product 1

HCID 10116086HCID 10116086, compoundYield 16.2%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Prepared as in Example 32 using 2-chloro-5-[(2-chloroethyl)amino]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (Example 29c, 0.200 g), 1-methylhistamine (0.400 g), N,N-diisopropylethylamine (1 ml), potassium iodide (0.080 g) and n-butanol (4 ml) to give the title compound as a gum (0.040 g).

Sources & evidence

ORD record
ord-c9640b5f3911429ca98c12c7751ac40c
Source dataset
uspto-grants-2004_04
Patent number
US06720452B2

Reaction notes

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