Toluene → HCID 22730840, compound

HRID 2085738Notes

Reaction equation

HRID 2085738 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][C:14]([CH2:21][CH2:22][C:23]([OH:25])=O)=[C:15]3[C:20]=2[N:19]=[CH:18][CH:17]=[CH:16]3)=[CH:7][CH:6]=1)=[O:4].C(Cl)(=O)C([Cl:29])=O.C1(C)C=CC=CC=1>ClCCl>[Cl:29][C:23](=[O:25])[CH2:22][CH2:21][C:14]1[CH:13]=[CH:12][C:11]([C:8]2[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=2)=[C:20]2[C:15]=1[CH:16]=[CH:17][CH:18]=[N:19]2

Participants

5

Reactant 3

HCID 1140TolueneHCID 65578Oxalyl chlorideHCID 22730792HCID 22730792, compound

Product 1

HCID 22730840HCID 22730840, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Example 201H (1.65 g, 4.92 mmol) in dichloromethane (15 mL) at room temperature was treated oxalyl chloride (344 mg, 2.71 mmol), stirred for 20 minutes, treated with toluene (25 mL), and concentrated to provide the desired product.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-a67bd1e8aea2444295db5e473a9d4fcf
Source dataset
uspto-grants-2004_04
Patent number
US06720338B2

Reaction notes

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