Water → 6-(3-Chlorophenoxy)-3-(2,6-difluorophenyl)-[1,2,4]triazine

HRID 2085924Notes

Reaction equation

HRID 2085924 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:9]=2[F:15])=[N:4][CH:3]=1.[Cl:16][C:17]1[CH:18]=[C:19]([OH:23])[CH:20]=[CH:21][CH:22]=1.C(=O)([O-])[O-].[K+].[K+].O>C(#N)C>[Cl:16][C:17]1[CH:18]=[C:19]([CH:20]=[CH:21][CH:22]=1)[O:23][C:2]1[N:7]=[N:6][C:5]([C:8]2[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:9]=2[F:15])=[N:4][CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 79333-ChlorophenolHCID 11430Potassium CarbonateHCID 227270216-Chloro-3-(2,6-difluorophenyl)-[1,2,4]triazine

Product 1

HCID 227270246-(3-Chlorophenoxy)-3-(2,6-difluorophenyl)-[1,2,4]triazine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

325 mg of 6-chloro-3-(2,6-difluorophenyl)-[1,2,4]triazine (see Example 1.7 b) are placed in 10 ml of acetonitrile; 230 mg of 3-chlorophenol and 190 mg of potassium carbonate are added and stirring is carried out at room temperature for 2 h. The reaction mixture is then poured into water and extracted with ethyl acetate; the ethyl acetate phase is concentrated and the crude product is purified by means of flash chromatography. In this way the title compound having a melting point of 132-137° C. is obtained.

Workup

  1. extractionextracted with ethyl acetate
  2. concentrationthe ethyl acetate phase is concentrated
  3. customthe crude product is purified by means of flash chromatography
  4. customis obtained

Sources & evidence

ORD record
ord-65d268edde04421f9d6540c5d795f061
Source dataset
uspto-grants-2004_04
Patent number
US06723720B2

Reaction notes

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