Ethanol → HCID 135817488, compound

HRID 2086107Notes

Reaction equation

HRID 2086107 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[N:10](CC(OCC)=O)[N:9]=1.[CH3:26][NH2:27].[CH2:28]([OH:30])[CH3:29]>>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[N:10]([CH2:29][C:28]([NH:27][CH3:26])=[O:30])[N:9]=1

Participants

4

Reactant 3

HCID 702Ethanol2×HCID 6329MethylamineHCID 135914986Ethyl [3,5bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate

Product 1

HCID 135817488HCID 135817488, compound

Conditions

Temperature
60 °C

Procedure

2.0 g of ethyl [3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate (Example 2) are dissolved in 15 ml of ethanol and treated with 0.8 ml of 8M methylamine in ethanol. The mixture is stirred at 60° C. for 3 h and then cooled. The crystals precipitating in the course of this are filtered off and washed with ethanol. After drying, 2-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-N-methylacetamide remains as colorless crystals m.p. 247-249 ° C.

Workup

  1. temperaturecooled
  2. customThe crystals precipitating in the course of
  3. filtrationthis are filtered off
  4. washwashed with ethanol
  5. customAfter drying

Sources & evidence

ORD record
ord-9e16b7d7eef14a06b581b536eaaddd84
Source dataset
uspto-grants-2004_04
Patent number
US06723742B2

Reaction notes

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