Hydrochloric Acid → 4-(6-Chloronaphthalene-2-sulfonyl)-1-[methyl(4-piperidinyl)amino]-2-piperazinone hydrochloride

HRID 2086243Notes

Reaction equation

HRID 2086243 reaction equation
C(OC(N1CCCCC1[CH2:14][NH:15][N:16]1[CH2:21][CH2:20][N:19]([S:22]([C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[C:30]([Cl:35])[CH:31]=3)[CH:26]=2)(=[O:24])=[O:23])[CH2:18][C:17]1=[O:36])=O)(C)(C)C.Cl.C(O[CH2:42][CH3:43])(=O)C>CO>[ClH:35].[Cl:35][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][CH:29]=1)[CH:26]=[C:25]([S:22]([N:19]1[CH2:20][CH2:21][N:16]([N:15]([CH3:14])[CH:43]3[CH2:42][CH2:21][NH:16][CH2:17][CH2:18]3)[C:17](=[O:36])[CH2:18]1)(=[O:24])=[O:23])[CH:34]=[CH:33]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl Acetate2×HCID 695455571-{[1-(Tert-butoxycarbonyl)piperidinyl]methylamino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone

Product 1

HCID 227272334-(6-Chloronaphthalene-2-sulfonyl)-1-[methyl(4-piperidinyl)amino]-2-piperazinone hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 1-{[1-(tert-butoxycarbonyl)piperidinyl]methylamino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone (10.42 g) in methanol (40 ml) was combined with a 4N solution of hydrochloric acid in ethyl acetate (20 ml) and stirred at room temperature for 5 hours. The reaction mixture was combined with ethyl acetate (50 ml) and the crystals precipitated were collected by filtration, dried to obtain the title compound (9.21 g) as colorless crystals.

Workup

  1. customthe crystals precipitated
  2. filtrationwere collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-0884c1b9927e412dbdeffe76aca42517
Source dataset
uspto-grants-2004_04
Patent number
US06723722B1

Reaction notes

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