Hydrochloric Acid → HCID 22727203, compound

HRID 2086288Notes

Reaction equation

HRID 2086288 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH:19]([CH3:21])[N:18]([N:22]([CH3:35])[CH:23]3[CH2:28][CH2:27][N:26]([C:29]4[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=4)[CH2:25][CH2:24]3)[C:17](=[O:36])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.Cl>C(O)C.C(OCC)(=O)C.C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH:19]([CH3:21])[N:18]([N:22]([CH3:35])[CH:23]3[CH2:24][CH2:25][N:26]([C:29]4[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=4)[CH2:27][CH2:28]3)[C:17](=[O:36])[CH2:16]1)(=[O:13])=[O:14])[CH:6]=[CH:5]2

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 22727184HCID 22727184, compound

Product 1

HCID 22727203HCID 22727203, compoundYield 203.6%

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

4-[(6-Chloro-2-naphthyl)sulfonyl]-6-methyl-1-[methyl[1-(4-pyridinyl)-4-piperidinyl]amino]-2-piperazinone (0.34 g) was dissolved in ethanol (2 ml) and combined with a 4N solution of hydrochloric acid in ethyl acetate (0.24 ml), ethyl acetate (20 ml) and diethyl ether (30 ml). The powder precipitated was collected by filtration and dried to obtain the title compound (0.37 g) as a colorless non-crystal powder.

Workup

  1. customThe powder precipitated
  2. filtrationwas collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-97b51ef649794aa18e2d82e75f096e5c
Source dataset
uspto-grants-2004_04
Patent number
US06723722B1

Reaction notes

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