反应详情

About 2 min after dissolving 3-[3-(4-fluorophenyl)isoxazol-5-yl]butanal (25 mg, 0.104 mmol) and 1-benzylpiperidine (37.2, 0.214 mmol) in 2 mL of dry methylene chloride, were added NaBH(OAc)3 (136 mg, 0.642 mmol), cold acetic acid (14.7, 0.257 mmol) and molecular sieves (5 beads). The reaction mixture was reacted for 1.5 hr and followed the same processes as in Example 1 to obtain 49.2 mg (58.4%) of the target compound.

1. customThe reaction mixture was reacted for 1.5 hr