1,4-dibenzyl-piperidine-4-carboxylic acid ethyl ester → HCID 22225015, compound

HRID 2086556Notes

Reaction equation

HRID 2086556 reaction equation
C([O:3][C:4]([C:6]1([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:12]([N:9]1[CH2:10][CH2:11][C:6]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([CH2:4][OH:3])[CH2:7][CH2:8]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 104971761,4-dibenzyl-piperidine-4-carboxylic acid ethyl esterHCID 21226445Aluminium lithium hydride

Product 1

HCID 22225015HCID 22225015, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Was prepared from 1,4-dibenzyl-piperidine-4-carboxylic acid ethyl ester (J. Chem. Soc., Perkin Trans. 1 1996, 20, 2545-2551.) by lithium aluminium hydride reduction in tetrahydrofurane under standard conditions in 81% yield. MS 296(M+H+).

Sources & evidence

ORD record
ord-ca754187376f4f79a4b6e5d116801871
Source dataset
uspto-grants-2004_04
Patent number
US06727247B2

Reaction notes

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