Hydrochloric Acid → HCID 22725089, compound

HRID 2086593Notes

Reaction equation

HRID 2086593 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[Cl:42])[N:10]1[CH:15]2[CH2:16][CH2:17][CH:11]1[CH2:12][C:13]([C:19]1[N:24]=[C:23]([NH:25][CH2:26][CH2:27][NH:28]C(=O)OC(C)(C)C)[CH:22]=[CH:21][CH:20]=1)([OH:18])[CH2:14]2>C(Cl)Cl>[NH2:28][CH2:27][CH2:26][NH:25][C:23]1[N:24]=[C:19]([C:13]2([OH:18])[CH2:14][CH:15]3[N:10]([CH:9]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=4[Cl:42])[C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=4[Cl:2])[CH:11]([CH2:17][CH2:16]3)[CH2:12]2)[CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid3×HCID 91490121HCID 91490121, compound

Product 1

HCID 22725089HCID 22725089, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
30 °C

Procedure

Add HCl (1N in ether, 0.36 ml) to a solution of the product from Step 2 (11 mg, 0.018 mmol) in CH2Cl2 at RT for 24 h. Add HCl (1N in ether, 0.36 ml) and stir at RT for 24 h. Add another 0.36 ml of HCl (1N in ether ) and stir at 30° C. for 24 h. Concentrate, treat with ether and filter to give the title compound as white solid. ESI-MS 497.1 (100, M+).

Workup

  1. concentrationConcentrate
  2. additiontreat with ether
  3. filtrationfilter

Sources & evidence

ORD record
ord-f826a8c8168447ad8d6d810db54520f5
Source dataset
uspto-grants-2004_04
Patent number
US06727254B2

Reaction notes

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