反应详情

温度

80 °C

A mixture of ethyl 4-hydroxy-3-methoxybenzoate (7.17 g), cyclopentyl bromide (4.7 ml) and potassium carbonate (7.6 g) in N,N-dimethylformamide (70 ml) was stirred at 80° C. for 3 hours. Then the mixture was poured into water and extracted with ethyl acetate twice. The combined organic solution was washed with water and brine, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel column (hexane-ethyl acetate, 4:1) to give ethyl 4-cyclopentyloxy-3-methoxybenzoate (8.58 g) as an oil.

1. extractionextracted with ethyl acetate twice
2. washThe combined organic solution was washed with water and brine
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. customThe residue was chromatographed on silica gel column (hexane-ethyl acetate, 4:1)