Sodium Bicarbonate → HCID 22724109, compound

HRID 2086881Notes

Reaction equation

HRID 2086881 reaction equation
[CH3:1][N:2]([C:6]1[CH:7]=[C:8]([N:12]2[C:17](=[O:18])[C:16]([CH2:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[N:15][C:14]3[CH:26]=[CH:27][CH:28]=[N:29][C:13]2=3)[CH:9]=[CH:10][CH:11]=1)C(=O)C.C(=O)(O)[O-].[Na+]>Cl>[CH3:1][NH:2][C:6]1[CH:7]=[C:8]([N:12]2[C:17](=[O:18])[C:16]([CH2:19][C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[N:15][C:14]3[CH:26]=[CH:27][CH:28]=[N:29][C:13]2=3)[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 22724018HCID 22724018, compound

Product 1

HCID 22724109HCID 22724109, compoundYield 58.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 4-[3-(N-methyl-N-acetylamino)phenyl]-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (2.02 g) in 3N hydrochloric acid (20 ml) was stirred under reflux for 2 hours. Then the mixture was poured into ice-water and alkalinized with sodium bicarbonate. The resultant solid was collected and washed with water and recrystallized from ethanol to give 4-[3-(methylamino)phenyl]-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (1.06 g).

Workup

  1. temperatureunder reflux for 2 hours
  2. customThe resultant solid was collected
  3. washwashed with water
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-ce2b7e18ad214cfab7eede77cad33371
Source dataset
uspto-grants-2004_04
Patent number
US06727245B2

Reaction notes

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