Hydrogen Bromide → HCID 22726020, compound

HRID 2087084Notes

Reaction equation

HRID 2087084 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([NH:11][CH2:12][CH2:13][CH3:14])[CH2:8][CH2:7][C:5]=2[N:6]=1.[BrH:15]>CO>[BrH:15].[NH2:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([NH:11][CH2:12][CH2:13][CH3:14])[CH2:8][CH2:7][C:5]=2[N:6]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 48854,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine

Product 1

HCID 22726020HCID 22726020, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.00 g of (±)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole was dissolved in 10 mL of hot methanol and 2.2 mL of 48% hydrobromic acid was added. The obtained suspension was stirred, cooled and precipitated solid was filtered off. The cake was washed with cold methanol and air-dried to give 2.7 g of (±)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole monohydrobromide with m.p. 236-245° C.

Workup

  1. temperaturecooled
  2. customprecipitated solid
  3. filtrationwas filtered off
  4. washThe cake was washed with cold methanol
  5. customair-dried

Sources & evidence

ORD record
ord-48c73cce3c344b4faecc611f4e487d12
Source dataset
uspto-grants-2004_04
Patent number
US06727367B2

Reaction notes

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