HRID2087797

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2774898

2-(4-chlorophenoxy)pyridine-3-carbonyl chloride

C12H7Cl2NO2

HCID16757470

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(=O)Nc1cccc(C2CCN(CCCNC(=O)c3cccnc3Oc3ccc(Cl)cc3)CC2)c1

HCID22048915

2-(4-Chlorophenoxy)-N-(3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}propyl)nicotinamide

C30H35ClN4O3

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 2-(4-chlorophenoxy)nicotinoyl chloride: ESMS m/e: 535.2 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bf0391bf22804dc6bd60643c495e4eb1
来源数据集: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06727264B1
来源说明: uspto-grants-2004_04

反应 SMILES

[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1.[Cl:23][C:24]1[CH:39]=[CH:38][C:27]([O:28][C:29]2[N:37]=[CH:36][CH:35]=[CH:34][C:30]=2[C:31](Cl)=[O:32])=[CH:26][CH:25]=1>C1COCC1>[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([O:28][C:29]2[N:37]=[CH:36][CH:35]=[CH:34][C:30]=2[C:31]([NH:1][CH2:2][CH2:3][CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:20])[CH3:21])[CH:12]=3)[CH2:7][CH2:6]2)=[O:32])=[CH:38][CH:39]=1