2-(4-Chlorophenoxy)pyridine-3-carbonyl chloride → 2-(4-Chlorophenoxy)-N-(3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}propyl)nicotinamide

HRID 2087797Notes

Reaction equation

HRID 2087797 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:21])[CH3:20])[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1.[Cl:23][C:24]1[CH:39]=[CH:38][C:27]([O:28][C:29]2[N:37]=[CH:36][CH:35]=[CH:34][C:30]=2[C:31](Cl)=[O:32])=[CH:26][CH:25]=1>C1COCC1>[Cl:23][C:24]1[CH:25]=[CH:26][C:27]([O:28][C:29]2[N:37]=[CH:36][CH:35]=[CH:34][C:30]=2[C:31]([NH:1][CH2:2][CH2:3][CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([NH:17][C:18](=[O:22])[CH:19]([CH3:20])[CH3:21])[CH:12]=3)[CH2:7][CH2:6]2)=[O:32])=[CH:38][CH:39]=1

Participants

4

Reactant 2

HCID 27748982-(4-Chlorophenoxy)pyridine-3-carbonyl chlorideHCID 16757470N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}2-methylpropanamide

Product 1

HCID 220489152-(4-Chlorophenoxy)-N-(3-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}propyl)nicotinamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(3-aminopropyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 2-(4-chlorophenoxy)nicotinoyl chloride: ESMS m/e: 535.2 (M+H)+.

Sources & evidence

ORD record
ord-bf0391bf22804dc6bd60643c495e4eb1
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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