2-Naphthoyl chloride → N-(2-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}ethyl)-2-naphthamide

HRID 2087806Notes

Reaction equation

HRID 2087806 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:11]=[C:12]([NH:16][C:17](=[O:21])[CH:18]([CH3:20])[CH3:19])[CH:13]=[CH:14][CH:15]=2)[CH2:6][CH2:5]1.[CH:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:23]=1[C:32](Cl)=[O:33]>C1COCC1>[C:17]([NH:16][C:12]1[CH:11]=[C:10]([CH:7]2[CH2:8][CH2:9][N:4]([CH2:3][CH2:2][NH:1][C:32]([C:23]3[CH:24]=[CH:25][C:26]4[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH:22]=3)=[O:33])[CH2:5][CH2:6]2)[CH:15]=[CH:14][CH:13]=1)(=[O:21])[CH:18]([CH3:19])[CH3:20]

Participants

4

Reactant 2

HCID 752462-Naphthoyl chlorideHCID 16757469N-(3-[1-(2-aminoethyl)-4-piperidinyl]phenyl)-2-methylpropanamide

Product 1

HCID 22048924N-(2-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}ethyl)-2-naphthamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by Procedure Q1 (THF) and Scheme AT using N-(3-[1-(2-aminoethyl)-4-piperidinyl]phenyl)-2-methylpropanamide and 2-naphthoyl chloride: ESMS m/e: 444. 2 (M+H)+.

Sources & evidence

ORD record
ord-a65d88279ee9425fb2ff5113f5f2066e
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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