3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride → 3-(2,6-Dichlorophenyl)-N-(5-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}pentyl)-5-methyl-4-isoxazolecarboxamide

HRID 2087808Notes

Reaction equation

HRID 2087808 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:14]=[C:15]([NH:19][C:20](=[O:24])[CH:21]([CH3:23])[CH3:22])[CH:16]=[CH:17][CH:18]=2)[CH2:9][CH2:8]1.[Cl:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[C:27]=1[C:33]1[C:37]([C:38](Cl)=[O:39])=[C:36]([CH3:41])[O:35][N:34]=1>C1COCC1>[Cl:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[C:27]=1[C:33]1[C:37]([C:38]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]2[CH2:8][CH2:9][CH:10]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([NH:19][C:20](=[O:24])[CH:21]([CH3:22])[CH3:23])[CH:14]=3)[CH2:11][CH2:12]2)=[O:39])=[C:36]([CH3:41])[O:35][N:34]=1

Participants

4

Reactant 2

HCID 782123-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chlorideHCID 16755867N-{3-[1-(5-aminopentyl)-4-piperidinyl]phenyl}-2-methylpropanamide

Product 1

HCID 220487233-(2,6-Dichlorophenyl)-N-(5-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}pentyl)-5-methyl-4-isoxazolecarboxamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(5-aminopentyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarbonyl chloride. ESMS m/e: 585.2 (M+H)+.

Sources & evidence

ORD record
ord-b59e5ca87f8f42e69b57e7d4879e865c
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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