Indole → 1-(3-Chloropropyl)-1H-indole

HRID 2087964Notes

Reaction equation

HRID 2087964 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.Br[CH2:11][CH2:12][CH2:13][Cl:14]>>[Cl:14][CH2:13][CH2:12][CH2:11][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 798IndoleHCID 80061-Bromo-3-chloropropane

Product 1

HCID 220489601-(3-Chloropropyl)-1H-indole

Procedure

Prepared by Procedure AH, and Scheme P using 1H-indole and 1-bromo-3-chloropropane: 1H NMR (400 MHz, CDCl3) δ 7.70-7.04 (m, 5H), 6.50 (d, 1H, J=2.8 Hz), 4.31 (t, 2H, J=6.8 Hz), 3.42 (t, 2H, J=6.4 Hz), 2.28-2.20 (m, 2H).

Workup

  1. customPrepared by Procedure AH, and Scheme P

Sources & evidence

ORD record
ord-e0d70b3c01144d0cb4ada29e37474cd1
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

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