反应详情

(1R*,2R*,5S*,6R*)-2-{[3,5-Bis(trifluoromethyl)phenyl]methoxy}-6-hydroxymethyl-1-phenyl-8-azabicyclo[3.2.1]octane (Example 29; 1.38 g, 2.5 mmol) in dichloromethane (6 ml) at room temperature was treated with Dess-Martin periodinane (1.07 g, 2.5 mmol) and stirred for 1 hour. The mixture was treated with 5% sodium hydrogen sulfite (50 ml) and saturated sodium hydrogen carbonate (30 ml) and stirred for 5 minutes. The organics were collected, washed with brine, dried (MgSO4) and concentrated in vacuo to afford the title compound as a yellow foam (1.24 g, 91%).

1. stirringstirred for 5 minutes
2. customThe organics were collected
3. washwashed with brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo