3-Aminopyridine → HCID 58182179, compound

HRID 2088424Notes

Reaction equation

C(OC([NH:8][C:9]1[S:13][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:11][C:10]=1[C:20]([OH:22])=O)=O)(C)(C)C.[NH2:23][C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1>>[NH2:8][C:9]1[S:13][C:12]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[N:11][C:10]=1[C:20]([NH:23][C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1)=[O:22]

Participants

Reactant 2

HCID 100093-Aminopyridine

HCID 58465104HCID 58465104, compound

Product 1

HCID 58182179HCID 58182179, compound

Procedure

Following the procedures as described in EXAMPLE 1 and starting with 5-(tert-butoxycarbonylamino)-2-phenylthiazole-4-carboxylic acid and 3-aminopyridine, the title compound was obtained as a white solid (21.0 mg, 42%). 1H NMR (400 MHz, DMSO) δ 9.78 (s, 1H), 8.99 (d, J=2.4, 1H), 8.30-8.18 (m, 2H), 7.95-7.88 (m, 2H), 7.59 (s, 2H), 7.53-7.32 (m, 4H). ESIMS m/z=297.1 (M+1).

Sources & evidence

ORD record: ord-cee2474679864a7a8bc113663b8bf8bd
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08435976B2

Reaction notes

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