反应详情

0.91 g of sodium cyanoborohydride was added to a methanol (100 mL) solution of 2 g of 5-nitroindan-2-amine sulfate and 1.9 g of (tert-butyldimethylsiloxy)acetaldehyde, and stirred at room temperature for 2 days. The reaction liquid was neutralized with aqueous saturated sodium bicarbonate solution, and methanol was evaporated away under reduced pressure. The residue was diluted with water, and extracted three times with chloroform. The organic layer was dried with anhydrous magnesium sulfate, the solvent was evaporated away under reduced pressure, and the crude product was purified through silica gel column chromatography (hexane/ethyl acetate) to obtain 1.56 g of the entitled compound as a yellow oil.

1. customThe reaction liquid
2. customwas evaporated away under reduced pressure
3. additionThe residue was diluted with water
4. extractionextracted three times with chloroform
5. dry with materialThe organic layer was dried with anhydrous magnesium sulfate
6. customthe solvent was evaporated away under reduced pressure
7. customthe crude product was purified through silica gel column chromatography (hexane/ethyl acetate)