Triethylamine → HCID 87192197, compound

HRID 2089060Notes

Reaction equation

HRID 2089060 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](S(C)(=O)=O)[N:5]=[C:4]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[N:14]([S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH:13]=2)[CH:3]=1.[CH:30]1([NH2:37])[CH2:35][CH2:34][CH2:33][CH:32]([NH2:36])[CH2:31]1.C(N(CC)CC)C>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[N:14]([S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH:13]=2)[N:5]=[C:6]([NH:36][CH:32]2[CH2:33][CH2:34][CH2:35][CH:30]([NH2:37])[CH2:31]2)[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 188141,3-CyclohexanediamineHCID 87192404HCID 87192404, compound

Product 1

HCID 87192197HCID 87192197, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of Example 42b (1 g, 2.23 mmol), cyclohexane-1,3-diamine (0.509 g, 4.46 mmol) and triethylamine (0.62 mL, 4.46 mmol) in dioxane (25 mL) was heated at 60° C. for 2 hours. The reaction mixture was concentrated and used directly for the next step.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-29beded1770d47d9b918dcd825964292
Source dataset
uspto-grants-2013_05
Patent number
US08435980B2

Reaction notes

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