Triethylamine → HCID 178511663, compound

HRID 2089064Notes

Reaction equation

HRID 2089064 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](S(C)(=O)=O)[N:5]=[C:4]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[N:14]([S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH:13]=2)[CH:3]=1.[C@H:30]1([NH2:37])[CH2:35][CH2:34][C@H:33]([NH2:36])[CH2:32][CH2:31]1.C(N(CC)CC)C>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[C:20]3[C:15](=[N:16][CH:17]=[CH:18][CH:19]=3)[N:14]([S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH:13]=2)[N:5]=[C:6]([NH:36][C@H:33]2[CH2:34][CH2:35][C@H:30]([NH2:37])[CH2:31][CH2:32]2)[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 87192404HCID 87192404, compoundHCID 178511674HCID 178511674, compound

Product 1

HCID 178511663HCID 178511663, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of Example 42b (5 g, 11.14 mmol), trans-cyclohexane-1,4-diamine (2.54 g, 22.28 mmol), triethylamine (3.10 mL, 22.28 mmol) and dioxane (120 mL) in a 250 mL of flask was heated at 60° C. for 90 minutes. The reaction mixture was concentrated and used directly for the next step.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-6ffddaa1a7b4443ca3a14594bc3a12ac
Source dataset
uspto-grants-2013_05
Patent number
US08435980B2

Reaction notes

Loading…