Tetrahydrofuran → 1H-indazol-3-amine

HRID 2089127Notes

Reaction equation

HRID 2089127 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[NH2:10]N.C1COCC1.O1CCOCC1>ClCCl>[NH2:10][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][N:2]=1

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 92211H-IndazoleHCID 9321HydrazineHCID 312751,4-Dioxane

Product 1

HCID 133991H-indazol-3-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Indazole (XV) is treated with hydrazine in an organic solvent such as THF, dioxane or dichloromethane, at a temperature in the range of about 0° C. to about 25° C., to yield the corresponding indazole (IV).

Sources & evidence

ORD record
ord-51eaac6dea544179a10339e7b1ceb214
Source dataset
uspto-grants-2013_05
Patent number
US08436023B2

Reaction notes

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