Piperidine → 1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine

HRID 2089369Notes

Reaction equation

Cl[C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>>[CH3:7][N:6]1[C:2]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:3]([N+:8]([O-:10])=[O:9])[CH:4]=[N:5]1

Participants

Reactant 2

HCID 8082Piperidine

HCID 123448365-chloro-1-methyl-4-nitro-1H-pyrazole

Product 1

HCID 34131191-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidineYield 89%

Procedure

Reaction of 5-chloro-1-methyl-4-nitro-1H-pyrazole and piperidine gave 1-(1-methyl-4-nitro-1H-pyrazol-5-yl)piperidine as a white solid (232 mg, 89%). 1H NMR (400 MHz, CDCl3) δ 8.00 (s, 1H), 3.74 (s, 3H), 3.18-3.12 (m, 4H), 1.74-1.63 (m, 6H)

Sources & evidence

ORD record: ord-ee51aa8e9a664edf9e4e04751073e4ff
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08436001B2

Reaction notes

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