Tetrahydro-4H-pyran-4-one → (Tetrahydropyran-4-yl)-(5-chloro-3-phenyl-1H-indol-7-yl)-amine

HRID 2089595Notes

Reaction equation

HRID 2089595 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:11]([O-])=O)[CH:10]=1)[NH:7][CH:6]=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[O:20]1[CH2:25][CH2:24][C:23](=O)[CH2:22][CH2:21]1>>[O:20]1[CH2:25][CH2:24][CH:23]([NH:11][C:9]2[CH:10]=[C:2]([Cl:1])[CH:3]=[C:4]3[C:8]=2[NH:7][CH:6]=[C:5]3[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 684718405-Chloro-3-phenyl-7-nitro-1H-indole

Product 1

HCID 25215218(Tetrahydropyran-4-yl)-(5-chloro-3-phenyl-1H-indol-7-yl)-amine

Procedure

5-Chloro-7-nitro-3-phenyl-1H-indole prepared in Preparation 41 and tetrahydropyran-4-one were reacted according to the same procedure as Example 1 to give the title compound.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c39072c89d61434eb6506e554cb4808b
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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