Dimethylamine → HCID 25106689, compound

HRID 2090246Notes

Reaction equation

HRID 2090246 reaction equation
[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:35][O:36][CH2:37][CH3:38])[N:14]([CH2:15][CH2:16][CH2:17][N:18]([CH2:23][C:24]3[CH:25]=[C:26]([CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH:27]=[CH:28][CH:29]=3)[C:19](=[O:22])[CH2:20]Cl)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[CH3:39][NH:40][CH3:41]>CN(C=O)C>[CH3:34][O:33][C:31](=[O:32])[CH2:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:24]([CH2:23][N:18]([CH2:17][CH2:16][CH2:15][N:14]2[C:10]3[C:9]4[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=4[N:3]=[C:2]([NH2:1])[C:11]=3[N:12]=[C:13]2[CH2:35][O:36][CH2:37][CH3:38])[C:19](=[O:22])[CH2:20][N:40]([CH3:41])[CH3:39])[CH:25]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 68432292HCID 68432292, compound

Product 1

HCID 25106689HCID 25106689, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product from step (vi) (30 mg) was dissolved in DMF (2 mL) then a solution of dimethylamine (2M in THF, 0.279 mL) was added at rt under nitrogen. The resulting solution was stirred at rt for 16 h. The mixture was purified by RPHPLC to give the title compound, yield 4.5 mg.

Workup

  1. customThe mixture was purified by RPHPLC

Sources & evidence

ORD record
ord-fce58ec914cd4d119d2ac232c5bdee8a
Source dataset
uspto-grants-2013_05
Patent number
US08436178B2

Reaction notes

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