反应详情

温度

50 °C

A solution of methyl 2-(3-formylphenyl)acetate (0.15 g) dissolved in NMP (10 mL) was added to a stirred solution of the product from step (i) (0.36 g) in NMP (10 mL) at rt. Sodium triacetoxyborohydride (0.90 g) was added to the mixture, the temperature was increased to 50° C. and the reaction mixture stirred for 24 h. The resulting solution was dissolved in methanol (0.5 mL), acidified with acetic acid (0.5 mL) and purified by SCX. The crude product was further purified by RPHPLC to give the title product, yield 22 mg.

1. custompurified by SCX
2. customThe crude product was further purified by RPHPLC