Hydrochloric Acid → HCID 131730564, compound

HRID 2090254Notes

Reaction equation

HRID 2090254 reaction equation
[ClH:1].[CH2:2]([C:6]1[N:7]([CH2:20][CH2:21][CH2:22][O:23][Si](C(C)(C)C)(C)C)[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[C:10]([NH2:18])[C:9]=2[N:19]=1)[CH2:3][CH2:4][CH3:5]>O1CCOCC1.CO>[ClH:1].[ClH:1].[NH2:18][C:10]1[C:9]2[N:19]=[C:6]([CH2:2][CH2:3][CH2:4][CH3:5])[N:7]([CH2:20][CH2:21][CH2:22][OH:23])[C:8]=2[C:17]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[N:11]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68431659HCID 68431659, compound

Product 1

HCID 131730564HCID 131730564, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

4M HCl in dioxane (12 mL) was added to a solution of the product from step (v) (6.7 g) in MeOH (100 mL) and stirred at rt for 18 h. The solvent was evaporated under reduced pressure, the residue triturated with diethyl ether, filtered and dried. Yield 5.53 g.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue triturated with diethyl ether
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-fb0690a396a4447baa5693f5e826a9b0
Source dataset
uspto-grants-2013_05
Patent number
US08436178B2

Reaction notes

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