反应详情

A mixture of the product from step (vii) (2 g), methyl 2-(3-(bromomethyl)phenyl)acetate (1.4 g) and potassium carbonate (2.1 g) in DMF (20 mL) was stirred at rt under nitrogen for 24 h. The mixture was partitioned between DCM/water, the organics separated, washed with water, dried, and evaporated under reduced pressure. The residue was purified by chromotography on silica eluting with DCM/MeOH/Et3N (1000/50/3). Yield 2.43 g of solid.

1. customThe mixture was partitioned between DCM/water
2. washthe organics separated, washed with water
3. customdried
4. customevaporated under reduced pressure
5. customThe residue was purified by chromotography on silica eluting with DCM/MeOH/Et3N (1000/50/3)