Hydrochloric Acid → Hydrochloric Acid

HRID 2090466Notes

Reaction equation

HRID 2090466 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9]2)=[CH:4][C:3]=1[F:19].[ClH:20].O1CCOCC1>C(OCC)(=O)C.C(OCC)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][NH:8][CH2:9]2)=[CH:4][C:3]=1[F:19].[ClH:20]

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59402372HCID 59402372, compound

Product 2

HCID 313Hydrochloric AcidHCID 59402294HCID 59402294, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 7-bromo-6-fluoro-3,4-dihydroisoquinoline-2(1H)-carboxylate (0.272 g, 1.0 mmol) in ethyl acetate (1 mL) was treated with 4.0 M of hydrogen chloride in 1,4-dioxane (1.0 mL, 4.0 mmol) at r.t. for 2 h. The mixture was diluted with ethyl ether, and centrifugalized. The solvents were decanted. The residue was dried in-vacuo to afford the desired product as HCl salt which was directly used in next step reaction without further purification.

Workup

  1. customThe solvents were decanted
  2. customThe residue was dried in-vacuo

Sources & evidence

ORD record
ord-630b37fc19ce4530be078233d5fddadb
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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