Hydrochloric Acid → HCID 178478256, compound

HRID 2090548Notes

Reaction equation

HRID 2090548 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13]1[NH:14][CH:15]=[C:16]([C:18]2[CH:19]=[C:20]([CH:45]=[CH:46][CH:47]=2)[O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[NH:32][C:31]([C@@H:33]4[CH2:37][CH2:36][CH2:35][N:34]4C(OC(C)(C)C)=O)=[N:30][CH:29]=3)=[CH:24][CH:23]=2)[N:17]=1)=O)(C)(C)C.[ClH:48]>ClCCl>[ClH:48].[NH:34]1[CH2:35][CH2:36][CH2:37][C@H:33]1[C:31]1[NH:32][C:28]([C:25]2[CH:26]=[CH:27][C:22]([O:21][C:20]3[CH:45]=[CH:46][CH:47]=[C:18]([C:16]4[N:17]=[C:13]([C@@H:9]5[CH2:10][CH2:11][CH2:12][NH:8]5)[NH:14][CH:15]=4)[CH:19]=3)=[CH:23][CH:24]=2)=[CH:29][N:30]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451926HCID 178451926, compound

Product 1

HCID 178478256HCID 178478256, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-tert-butyl 2-(5-(4-(3-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)phenoxy)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (500 mg, 0.78 mmol) in dichloromethane was added HCl (1 M, 3 mL), the reaction product precipitated after stirring at room temperature. Filtration and drying in the vacuum oven afforded 2-((S)-pyrrolidin-2-yl)-5-(4-(3-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-4-yl)phenoxy)phenyl)-1H-imidazole hydrochloride (220 mg).

Workup

  1. customthe reaction product precipitated
  2. filtrationFiltration
  3. customdrying in the vacuum oven

Sources & evidence

ORD record
ord-28f163613cbd4444a563c6617e6247d1
Source dataset
uspto-grants-2013_05
Patent number
US08436036B2

Reaction notes

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