6-Acetyltetralin → 2-Bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one

HRID 2090593Notes

Reaction equation

HRID 2090593 reaction equation
[CH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[C:11](=[O:13])[CH3:12].[Br-:14].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1>C1COCC1>[Br:14][CH2:12][C:11]([C:2]1[CH:3]=[CH:4][C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10]=2[CH:1]=1)=[O:13]

Participants

4

Reactant 2

HCID 698856-AcetyltetralinHCID 17977687Phenyltrimethylammonium bromide dibromide

Product 1

HCID 73539912-Bromo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

25 g (143 mmol) of 1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethanone are dissolved in 750 ml of THF, 64.7 g (172 mmol) of phenyltrimethylammonium tribromide are added, and the mixture is stirred at room temperature for 15 h.

Sources & evidence

ORD record
ord-52019c7f0fde4a39bdb69c5d85775165
Source dataset
uspto-grants-2013_05
Patent number
US08436186B2

Reaction notes

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