Hydrochloric Acid → HCID 44185218, compound

HRID 2090814Notes

Reaction equation

HRID 2090814 reaction equation
[ClH:1].[CH3:2][N:3]1[CH2:8][CH2:7][CH:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15](=[O:32])[CH2:16][O:17][CH2:18][CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][N:20]3C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH2:5][CH2:4]1>C(OCC)(=O)C.C(OCC)C>[ClH:1].[ClH:1].[ClH:1].[CH3:2][N:3]1[CH2:4][CH2:5][CH:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15](=[O:32])[CH2:16][O:17][CH2:18][CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][NH:20]3)[CH2:11][CH2:10]2)[CH2:7][CH2:8]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59746485HCID 59746485, compound

Product 1

HCID 44185218HCID 44185218, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
45 °C

Procedure

Hydrogen chloride (26.0 ml, 52.10 mmol, 2 M solution in diethyl ether) was added at room temperature to a solution of tert-butyl 2-((2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-2-oxoethoxy)methyl)piperidine-1-carboxylate (4.57 g, 10.42 mmol) in a mixture of ethyl acetate (15 ml) and diethyl ether (50 ml). The reaction mixture was stirred for 2 h at 45° C. Then the resulting white solid was filtered off and dried.

Workup

  1. filtrationThen the resulting white solid was filtered off
  2. customdried

Sources & evidence

ORD record
ord-c542dbcf28ab4a1cb49ca576b143e8ad
Source dataset
uspto-grants-2013_05
Patent number
US08435978B2

Reaction notes

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