Hydrochloric Acid → HCID 67456532, compound

HRID 2090816Notes

Reaction equation

HRID 2090816 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([S:11]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH:15]2[CH2:20][O:21][CH2:22][C:23]([N:25]2[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]2)=[O:24])(=[O:13])=[O:12])=[C:6]([CH3:38])[CH:5]=1>C(OCC)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[C:8]([CH3:10])[C:7]([S:11]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH:15]2[CH2:20][O:21][CH2:22][C:23]([N:25]2[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]2)=[O:24])(=[O:12])=[O:13])=[C:6]([CH3:38])[CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59746481HCID 59746481, compound

Product 1

HCID 67456532HCID 67456532, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Hydrogen chloride (1.15 ml, 2.30 mmol, 2 M solution in diethyl ether) was added at room temperature to a solution of tert-butyl 4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazine-1-carboxylate (Example 101) (310 mg, 0.574 mmol) in diethyl ether (2-5 ml). The reaction mixture was stirred for 2 h at room temperature and then refluxed for 10 min. The resulting solid was filtered off and dried. Yield: 210 mg (77%), white solid

Workup

  1. temperaturerefluxed for 10 min
  2. filtrationThe resulting solid was filtered off
  3. customdried

Sources & evidence

ORD record
ord-56563695f91e4909b71e941abd34532c
Source dataset
uspto-grants-2013_05
Patent number
US08435978B2

Reaction notes

Loading…