Hydrazine hydrate (1:1) → HCID 178498884, compound

HRID 2090841Notes

Reaction equation

HRID 2090841 reaction equation
[CH:1]1([C:4](=O)[CH2:5][C:6]([O:8][CH3:9])=[O:7])[CH2:3][CH2:2]1.COC(OC)[N:14]([CH3:16])C.O.[NH2:20]N>>[CH:1]1([C:4]2[C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:16][NH:14][N:20]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 78373Dimethylformamide dimethyl acetalHCID 101300163-Cyclopropyl-3-Oxopropionic Acid Methyl Ester

Product 1

HCID 178498884HCID 178498884, compound

Procedure

Using methyl 3-cyclopropyl-3-oxopropanoate (2.8 g), dimethylformamide dimethylacetal (2.8 mL) and hydrazine monohydrate (1.1 mL) and in the same manner as in Example 1(3), a crude product of methyl 3-cyclopropyl-1H-pyrazole-4-carboxylate was obtained. This was dissolved in dimethylformamide (30 ml), potassium carbonate (4.2 g) and 2-chloro-5-trifluoromethylpyridine (3.6 g) were added, and the mixture was stirred at 100° C. for 2 hr. In the same manner as in Example 1(4), the title object compound (4.8 g, 77%) was obtained as a white solid.

Sources & evidence

ORD record
ord-91aa827ed59a46898a4992751dbf8dce
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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